¾ð·Ð»ç
ÀÔ·Â : 2020.11.25 08:51
- ¾ÆÁִ뺴¿ø ±èöȣ ±³¼ö
[ÀÇÇнŹ®¡¤ÀÏ°£º¸»ç=ÀÌ»ó¸¸ ±âÀÚ] ¾ÆÁִ뺴¿ø À̺ñÀÎÈÄ°ú ±èöȣ ±³¼ö°¡ Áö³ 12~13ÀϱîÁö ¾çÀÏ°£ °³ÃÖµÈ Á¦46Â÷ ´ëÇѾÏÇÐȸ Çмú´ëȸ ¹× Á¦6Â÷ ±¹Á¦¾ÏÄÁÆÛ·±½º¿¡¼ `Merit Award` Çмú»óÀ» ¼ö»óÇß´Ù.
ÀÌ»óÀº ´ëÇѾÏÇÐȸ Çмú´ëȸ¿¡¼ ¸Å³â ¹ßÇ¥µÇ´Â ³í¹® ÃÊ·Ï Áß ¾Ï ¿¬±¸¿Í ¾Ï ȯÀÚ Ä¡·á ¹ßÀü¿¡ ±â¿©ÇÒ ¼ö ÀÖ´Â ¿ì¼ö ¿¬Á¦¸¦ ¼±Á¤ÇØ ¼ö¿©ÇÏ´Â »óÀÌ´Ù.
À̹ø¿¡ ¼ö»óÇÑ ¿¬Á¦´Â `Cross-talking between HSPA5 arginylation and sequential ubiquitination leads to lysosomal degradation of AKT`·Î, ¾Ï¼¼Æ÷ Áõ½Ä, »ýÁ¸°ú Àç¹ß¿¡ Áß¿äÇÑ ½ÅÈ£Àü´ÞüÀÎ AKT ´Ü¹éÁúÀÌ ÇÁ·ÎÅ×¾ÆÁ»(proteasome)ÀÌ ¾ïÁ¦µÆÀ» ¶§ MUL1 ´Ü¹éÁú·Î ÀÎÇØ ÀÚ°¡Æ÷½Ä(autophagy) ºÐÇØµÇ¾î ±Ã±ØÀûÀ¸·Î ¾Ï¼¼Æ÷ »ç¸êÀ» À¯µµÇÑ´Ù´Â ÃÖÃÊÀÇ ±âÀü ¿¬±¸´Ù.
±èöȣ ±³¼ö´Â À̹ø ¿¬±¸¸¦ ÅëÇØ MUL1ÀÇ ½Å±Ô `´Ü¹éÁú ºÐÇØ ¸ÞÄ¿´ÏÁò`À» ±Ô¸íÇÔÀ¸·Î½á, Ç×¾ÏÁ¦ ³»¼ºÀ» ±Øº¹ÇÒ ¼ö ÀÖ´Â ÀÌ·ÐÀû ±Ù°Å°¡ µÇ¾ú°í, ÇâÈÄ ¾Ï ³»¼º ±Øº¹À» À§ÇÑ È¿°úÀûÀÎ º´ÇÕÄ¡·áÁ¦ °³¹ß·Î À̾îÁú °¡´É¼ºÀÌ ÀÖ´Ù°í ¹àÇû´Ù.
±èöȣ ±³¼ö´Â ´ëÇÑÀ̺ñÀÎÈÄ°úÇÐȸ ±³À°¿¬±¸ÀÌ»ç, ´ëÇѵΰæºÎÁ¾¾çÇÐȸ Ãѹ«ÀÌ»ç¿Í ÇмúÀÌ»ç, ´ëÇѼҾÆÀ̺ñÀÎÈÄ°úÇÐȸ ÇмúÀÌ»ç, ´ëÇÑ°©»ó¼±µÎ°æºÎ¿Ü°úÇÐȸ ÇмúÀÌ»ç, ´ëÇѱâ°ü½ÄµµÇÐȸ »óÀÓÀÌ»ç, Tissue Engineering and Rehabilitation Medicine Àú³Î Vice Editor µîÀ» ¿ªÀÓÇßÀ¸¸ç, 2021³âºÎÅÍ ´ëÇѼҾÆÀ̺ñÀÎÈÄ°úÇÐȸÀåÀ¸·Î È°µ¿ÇÒ ¿¹Á¤ÀÌ´Ù.
ÀÇÇнŹ®
ÀÇÇнŹ® ÀÌ»ó¸¸ ±âÀÚ
smlee@bosa.co.kr